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Sulfates are the major circulating conjugates of ethinyl estradiol and glucuronides predominate in urine. The principal oxidative metabolite is 2-hydroxy ethinyl estradiol, shaped from the CYP3A4 isoform of cytochrome P450. Part of the main-pass metabolism of ethinyl estradiol is thought to come about in gastrointestinal mucosa. Ethinyl estradiol m